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Kobzar, N.
- Prediction of Antitumor Activity of 3-substituted Quinazolinone Derivatives Synthesized in One-pot Method Catalyzed by Bi(Otf)3
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Authors
L. Perekhoda
1,
M. Hari Krishna
2,
T . Sekhar
2,
A. Venkateswarlu
2,
P. Thriveni
2,
M. Suleiman
1,
A. Semenets
1,
A. Fedosov
1,
L. Grinevich
1,
N. Kobzar
1,
V. Yaremenko
1
Affiliations
1 Department of Medicinal Chemistry, National University of Pharmacy, Pushkinska 53, 61002, Kharkiv,, UA
2 Department of Chemistry, Vikrama Simhapuri University, Nellore-524001, Andhra Pradesh,, IN
1 Department of Medicinal Chemistry, National University of Pharmacy, Pushkinska 53, 61002, Kharkiv,, UA
2 Department of Chemistry, Vikrama Simhapuri University, Nellore-524001, Andhra Pradesh,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 559-565Abstract
A series of 3-substituted guinazolinone derivatives have been synthesized in good to excellent yields and high selectivity by one-pot reaction using anthranilic acid, amine and orthoester in ethanol under mild conditions, respectively. The reaction was efficiently promoted by Bi(OTf)3 and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity. Docking studies have shown that the tested molecules have an affinity for anticancer targets. The data obtained can be used in planning experimental screening for antitumor activity.Keywords
Synthesis, Bi(OTf)3, anthranilic acid, orthoester, one-pot union, аmine, quinazolinone derivatives, molecular docking, antitumor activity.
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